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Nevertheless, Glenn Micalizio, a chemist at Scripps, and his colleagues did n
The main asymmetric total synthesis of conolidine was created by Micalizio and coworkers in 2011.[two] This synthetic route enables access to both enantiomer (mirror impression) of conolidine through an early enzymatic resolution.
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An extra eight measures introduced them for their target. Every stage in the synthesis inevitably produces some aspect merchandise, so not most of the starting substance finally ends up as conolidine. But 18% of it does--a respectable proportion for a complicated synthesis.
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